CONTENTS

Review

Intestinal Absorption of Drugs Mediated by Drug Transporters: Mechanisms and Regulation Toshiya KATSURA and Ken-ichi INUI

1

Regular Article

Potential Cholestatic Activity of Various Therapeutic Agents Assessed by Bile Canalicular Membrane Vesicles Isolated from Rats and Humans Masato HORIKAWA, Yukio KATO, Charles A. TYSON and Yuichi SUGIYAMA	16
Enhanced Permeability of Phenylalanyl-glycine (Phe-Gly) Across the Intestinal Membranes by Chemical Modification with Various Fatty Acids Akira YAMAMOTO, Yutaka MORISHITA, Shinichi SUGISHITA, Teruko HAYAMI, Naoki OKADA, Takuya FUJITA and Shozo MURANISHI	23
Function of Uptake Transporters for Taurocholate and Estradiol 17β-D-Glucuronide in Cryopreserved Human Hepatocytes Yoshihisa SHITARA, Albert P. LI, Yukio KATO, Chuang LU, Kiyomi ITO, Tomoo ITOH and Yuichi SUGIYAMA	33
Large-scale Production of Genetically Engineered CYP3A4 in E. coli: Application of a Jarfermenter Yoichi KANAMORI, Ken-ichi FUJITA, Kazuo NAKAYAMA, Hideki KAWAI and Tetsuya KAMATAKI	42
Bioinformatics Research on Inter-racial Difference in Drug Metabolism I. Analysis on Frequencies of Mutant Alleles and Poor Metabolizers on CYP2D6 and CYP2C19 Takako SHIMIZU, Hirohide OCHIAI, Fredrik ASELL, Hiroshi SHIMIZU, Ryuta SAITOH, Yoshimasa HAMA, Jun KATADA, Munehiro HASHIMOTO, Hitoshi MATSUI, Katsuhiko TAKI, Tsuguchika KAMINUMA, Michiko YAMAMOTO, Yoshitaka AIDA, Akira OHASHI and Naoki OZAWA	48
Bioinformatics Research on Inter-racial Difference in Drug Metabolism II. Analysis on Relationship between Enzyme Activities of CYP2D6 and CYP2C19 and their Relevant Genotypes Takako SHIMIZU, Hirohide OCHIAI, Fredrik ASELL, Yoshiya YOKONO, Yoshiharu KIKUCHI, Masashi NITTA, Yoshimasa HAMA, Shizuyo YAMAGUCHI, Munehiro HASHIMOTO, Katsuhiko TAKI, Kotoko NAKATA, Yoshitaka AIDA, Akira OHASHI and Naoki OZAWA	71
Alteration in Catalytic Properties of Human CYP2D6 Caused by Substitution of Glycine-42 with Arginine, Lysine and Glutamic Acid Daisuke TSUZUKI, Hiroyuki HICHIYA, Yukie OKUDA, Shigeo YAMAMOTO, Keietsu TAMAGAKE, Sumio SHINODA and Shizuo NARIMATSU	79

SNP Communication

Eighteen Novel Polymorphisms of the CYP2A13 Gene in Japanese Masaki FUJIEDA, Hiroshi YAMAZAKI, Kazuma KIYOTANI, Asami MUROI, Hideo KUNITOH, Hirotoshi DOSAKA-AKITA, Yuichi SAWAMURA and Tetsuya KAMATAKI

SNP1 (86)