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DMPK Editors' Award for the Most Excellent Article in 2021
- 【1st Place】
Yukihiro Shibata, Yuta Tamemoto, Sheelendra Pratap Singh, Aoi Yoshitomo, Shizuka Hozuki, Hiromi Sato, Akihiro Hisaka*
Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6.
Volume 39, 100396, August 2021.
https://doi.org/10.1016/j.dmpk.2021.100396
- 【2nd Place】
Katsunori Sasahara*, Masakazu Shibata, Hiroyuki Sasabe, Tomoki Suzuki, Kenji Takeuchi, Ken Umehara, Eiji Kashiyama
Predicting drug metabolism and pharmacokinetics features of in-house compounds by a hybrid machinelearning model.
Volume 39, 100395, August 2021.
https://doi.org/10.1016/j.dmpk.2021.100395
- 【3rd Place】
Chikako Shibazaki, Tomoyuki Ohe, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino*
Development of fluorescent-labeled trapping reagents based on cysteine to detect soft and hard electrophilic reactive metabolites.
Volume 39, 100386, August 2021.
https://doi.org/10.1016/j.dmpk.2021.100386
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DMPK Editors' Award for the Most Excellent Article in 2020
- 【1st Place】
6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients
Yusuke Masuo, Ken-ichi Fujita, Kenji Mishiro, Natsumi Seba, Tatsuya Kogi, Hidenori Okumura, Natsumi Matsumoto, Munetaka Kunishima, Yukio Kato
Volume 35, Issue 6, Pages 555-562
https://doi.org/10.1016/j.dmpk.2020.09.001
- 【2nd Place】
Pharmacokinetic functions of human induced pluripotent stem cell-derived small intestinal epithelial cells
Tomoki Kabeya, Shinji Mima, Yuki Imakura, Toshihide Miyashita, Izumi Ogura, Tadanori Yamada, Tomoya Yasujima, Hiroaki Yuasa, Takahiro Iwao, Tamihide Matsunaga
Volume 35, Issue 4, Pages 374-382
https://doi.org/10.1016/j.dmpk.2020.04.334
- 【3rd Place】
Quantitative application of flow cytometry for the analysis of circulating human T cells: A preclinical pharmacokinetic study
Syunsuke Yamamoto, Shin-Ichi Matsumoto, Hisao Shimizu, Hideki Hirabayashi
Volume 35, Issue 2, Pages 207-213
https://doi.org/10.1016/j.dmpk.2019.11.003
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DMPK Editors' Award for the Most Excellent Article in 2019
- 【1st Place】
Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers
Daiki Mori, Yushi Kashihara, Takashi Yoshikado, Miyuki Kimura, Takeshi Hirota, Shunji Matsuki, Kazuya Maeda, Shin Irie, Ichiro Ieiri, Yuichi Sugiyama, Hiroyuki Kusuhara
Volume 34, Issue 1, Pages 78-86
https://doi.org/10.1016/j.dmpk.2018.09.003
- 【2nd Place】
Quantitative investigation of hepatobiliary transport of [11C]telmisartan in humans by PET imaging
Kazuya Maeda, Akihito Ohnishi, Masahiro Sasaki, Yasuhiko Ikari, Kazuki Aita, Yasuyoshi Watanabe, Hiroyuki Kusuhara, Yuichi Sugiyama, Michio Senda
Volume 34, Issue 5, Pages 293-299
https://doi.org/10.1016/j.dmpk.2019.02.004
- 【3rd Place】
Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney
Tomoko Kito, Sumito Ito, Tadahaya Mizuno, Kazuya Maeda, Hiroyuki Kusuhara
Volume 34, Issue 1, Pages 87-94
https://doi.org/10.1016/j.dmpk.2018.08.005
- 【3rd Place】
Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients
Nora Lee, Kazuya Maeda, Shinya Fukizawa, Ichiro Ieiri, Atsuko Tomaru, Hironobu Akao, Kenji Takeda, Mizuho Iwadare, Osamu Niwa, Tougen Masauji, Naoe Yamane, Kouji Kajinami, Hiroyuki Kusuhara, Yuichi Sugiyama
Volume 34, Issue 6, Pages 387-395
https://doi.org/10.1016/j.dmpk.2019.08.004
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DMPK Editors' Award for the Most Excellent Article in 2018
- 【1st Place】
Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model
Tomohisa Nakada, Toshiyuki Kudo, Toshiyuki Kume, Hiroyuki Kusuhara, Kiyomi Ito
Volume 33, Issue 1, Pages 103-110, 2018
https://doi.org/10.1016/j.dmpk.2017.11.314
- 【2nd Place】
miR-141-3p commonly regulates human UGT1A isoforms via different mechanisms
Naoyuki Tatsumi, Shinsaku Tokumitsu, Masataka Nakano, Tatsuki Fukami, Miki Nakaj
ima Volume 33, Issue 4, Pages 203-210, 2018
https://doi.org/10.1016/j.dmpk.2018.05.002
- 【3rd Place】
Physiological based pharmacokinetic modeling to estimate in vivo Ki of ketoconazole on renal P-gp using human drug-drug interaction study result of fesoterodine and ketoconazole
Masayo Oishi, Yuma Takano, Yutaka Torita, Bimal Malhotra, Koji Chiba
Volume 33, Issue 1, Pages 90-95, 2018
https://doi.org/10.1016/j.dmpk.2017.11.005
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DMPK Editors' Award for the Most Excellent Article in 2017
- 【1st Place】
Quantitative prediction of therapeutic antibody pharmacokinetics after intravenous and subcutaneous injection in human
Kenta Haraya, Tatsuhiko Tachibana, Junichi Nezu
Volume 32, Issue 4, 2017, Pages 208-217
https://doi.org/10.1016/j.dmpk.2017.05.002
- 【2nd Place】
Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates
Toru Takenaka, Kanako Kazuki, Naomoto Harada, Jiro Kuze, Masato Chiba, Takahiro Iwao, Tamihide Matsunaga, Satoshi Abe, Mitsuo Oshimura, Yasuhiro Kazuki
Volume 32, Issue 1, 2017, Pages 61-68
https://doi.org/10.1016/j.dmpk.2016.08.004
- 【3rd Place】
Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data
Kayoko Kanamitsu, Yoshitane Nozaki, Yoko Nagaya, Yuichi Sugiyama, Hiroyuki Kusuhara
Volume 32, Issue 2, 2017, Pages 135-144
https://doi.org/10.1016/j.dmpk.2016.11.007
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DMPK Editors' Award for the Most Excellent Article in 2016
- 【1st Place】
Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments
Kanamitsu K., Arakawa R., Sugiyama Y., Suhara T., Kusuhara H.
Vol. 31 (2016) No. 6 p. 395-404
http://www.sciencedirect.com/science/article/pii/S1347436716300441
- 【2nd Place】
Investigation of utility of cerebrospinal fluid drug concentration as a surrogate for
interstitial fluid concentration using microdialysis coupled with cisternal cerebrospinal fluid sampling in wild-type and Mdr1a(−/−) rats
Nagaya Y., Nozaki Y., Takenaka O., Watari R., Kusano K., Yoshimura T., Kusuhara H.
Vol. 31 (2016) No. 1 p. 57-66
http://www.sciencedirect.com/science/article/pii/S1347436715000622
- 【3rd Place】
Inhibition of mitogen-activated protein kinase kinase, DNA methyltransferase, and
transforming growth factor-β promotes differentiation of human induced pluripotent stem cells into
enterocytes
Kodama N., Iwao T., Kabeya T., Horikawa T., Niwa T., Kondo Y., Nakamura K., Matsunaga T.
Vol. 31 (2016) No. 3 p. 193-200
http://www.sciencedirect.com/science/article/pii/S134743671600015X
- 【3rd Place】
Development of a permeability-limited model of the human brain and cerebrospinal fluid(CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data
Gaohua L., Neuhoff S., Johnson T.N., Rostami-Hodjegan A., Jamei M.
Vol. 31 (2016) No. 3 p. 224-233
http://www.sciencedirect.com/science/article/pii/S1347436716300088
- 【3rd Place】
Appropriate risk criteria for OATP inhibition at the drug discovery stage based on the
clinical relevancy between OATP inhibitors and drug-induced adverse effect
Nakakariya M., Goto A., Amano N.
Vol. 31 (2016) No. 5 p. 333-339
http://www.sciencedirect.com/science/article/pii/S1347436716300234
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