CONTENTS

Reviews

CYPalleles: A Web Page for Nomenclature of Human Cytochrome P450 Alleles Mikael OSCARSON and Magnus INGELMAN-SUNDBERG	491
Kinetic Impact of Presystemic Intestinal Metabolism on Drug Absorption: Experiment and Data Analysis for the Prediction of In Vivo Absorption from In Vitro Data Takashi MIZUMA	496

Regular Articles

Species Differences in the Metabolism of (+)- and (--)-Limonenes and their Metabolites, Carveols and Carvones, by Cytochrome P450 Enzymes in Liver Microsomes of Mice, Rats, Guinea Pigs, Rabbits, Dogs, Monkeys, and Humans Tsutomu SHIMADA, Masaki SHINDO and Mitsuo MIYAZAWA	507
Major Cytochrome P450 Enzymes Responsible for Microsomal Aldehyde Oxygenation of 11-Oxo-Δ8-tetrahydrocannabinol and 9-Anthraldehyde in Human Liver Kazuhito WATANABE, Tamihide MATSUNAGA, Toshiyuki KIMURA, Tatsuya FUNAHASHI, Yoshihiko FUNAE, Tohru OHSHIMA and Ikuo YAMAMOTO	516
Effects of Serum Albumin and Liver Cytosol on CYP2C9- and CYP3A4-mediated Drug Metabolism Takahiko BABA, Akira TOUCHI, Kiyomi ITO, Yoshitaka YAMAGUCHI, Yasushi YAMAZOE, Yasuo OHNO and Yuichi SUGIYAMA	522
Determination of a Novel Haplotype of β2-adrenergic Receptor in the Japanese Population by the Combination of the Electronic Microchip Assay Using the NanoChip System with Allele-specific PCR Nobuyo YOSHIDA, Masahide SUGIYAMA, Akito TANOUE, Akira HIRASAWA, Hirohisa SAITO and Gozoh TSUJIMOTO	532
Plasma Retinol Binding Protein for Monitoring the Acetaminophen-induced Hepatotoxicity Masanao ISOZAKI, Kousei ITO, Yasuhiro MASUBUCHI and Toshiharu HORIE	540
Metabolic Extraction of Nifedipine during Absorption from the Rat Small Intestine Takahiro IWAO, Katsuhisa INOUE, Yayoi HAYASHI, Hiroaki YUASA and Jun WATANABE	546
Involvement of Specific Transport System of Renal Basolateral Membranes in Distribution of Nicotine in Rats Atsuko FUKADA, Hideyuki SAITO, Yumiko URAKAMI, Masahiro OKUDA and Ken-ichi INUI	554

SNP Communications

Eleven Novel Single Nucleotide Polymorphisms in the NR1I2 (PXR) Gene, Four of which Induce Non-synonymous Amino Acid Alterations Satoru KOYANO, Kouichi KUROSE, Shogo OZAWA, Mayumi SAEKI, Yukiko NAKAJIMA, Ryuichi HASEGAWA, Kazuo KOMAMURA, Kazuyuki UENO, Shiro KAMAKURA, Toshiharu NAKAJIMA, Hirohisa SAITO, Hideo KIMURA, Yu-ichi GOTO, Osamu SAITOH, Masaaki KATOH, Teiichi OHNUMA, Mitsuru KAWAI, Kenji SUGAI, Taisuke OHTSUKI, Chieko SUZUKI, Narihiro MINAMI, Yoshiro SAITO, and Jun-ichi SAWADA

SNP27 (561)

Twelve Novel Single Nucleotide Polymorphisms in ABCB1/MDR1 among Japanese Patients with Ventricular Tachycardia who were Administered Amiodarone Masaya ITODA, Yoshiro SAITO, Kazuo KOMAMURA, Kazuyuki UENO, Shiro KAMAKURA, Shogo OZAWA and Jun-ichi SAWADA

SNP32 (566)

Table of Contents Volume 17, No. 1‾No. 6

573

Author Index

579