Newsletter Volume 40, Number 4, 2025
Introduction
After the record-breaking heat wave that began in late June, we are still suffering from the intense heat. This summer, heavy rains caused by linear precipitation zones have been reported in many parts of Japan, and we would like to express our deepest sympathies to those who have been affected by these disasters. This is the time of year when we are reminded once again how grateful we are for our daily lives in the face of nature’s fury.
In the midst of all this, I personally feel a little saddened by the news. Legends that I admired and was a fan of in my youth and school days, such as Ozzy Osbourne and Hulk Hogan, have passed away, and I feel as if I am reaching a turning point of the times. I feel a little bit choked up when I recall the days when I was encouraged by their appearance…. On the other hand, young Japanese swimmers have shown us wonderful performances at the World Swimming Championships, and Shohei Ohtani has been surprising and inspiring us day after day in the MLB, especially since the beginning of August. When we are touched by such bright topics, we can feel hope and energy for the future, which naturally makes us feel positive!
The 40th Annual Meeting of the Japanese Society of Pharmacokinetics and Pharmacodynamics, which will be held at Miyakomesse, Kyoto, Japan, is just a little over two months away. The theme of this year’s meeting is “Intersection of Innovation for the Future of Drug Discovery and Medicine”. The 17th Short Course on “Perspectives of Pharmacokinetic Research for Drug Discovery and Development” will be held prior to the Annual Meeting. This year’s meeting will be full of exciting events, and we hope you will find it stimulating and meaningful. In this issue, we have included a special feature article with a message from the chairs of each meeting, as well as video clips from representatives of each symposium introducing the highlights of their respective symposiums. We hope you will enjoy these articles as well as the “Introduction of Technology and Research Materials” article, which is also a must-see. (Y.N.)
Topics
Highlights of the 40th Annual Meeting in Kyoto and the 17th Short Course, as told by the President of the Annual Meeting and the Chairperson of the Executive Committee
Tomiyoshi Yamashita, President of the 40th Annual Meeting in Kyoto, and Shingo Sakamoto, Chair of the 17th Short Course Executive Committee, talk about “Highlights and Things to See and Hear”. How can we make the most of and enjoy the conference and short course? If you are interested in attending, or even if you are on the fence, please take a look at this article before making a final decision. … ( To be continued on the NL homepage )
Check it out easily with the short video! Highlights of the 40th Annual Meeting in Kyoto
If you are not sure which symposium to attend at the 40th Annual Meeting in Kyoto, please check the “Highlights” of each symposium by watching the short videos created by the organizers and chairpersons. … ( To be continued on the NL website)
Introduction of Technology and Research Materials (Company Advertisement)
Improvement of Reproducibility and Quantitation in Nucleotide Analysis by Suppression of Metal Adsorption
Analytical and Measuring Division, Shimadzu Corporation
Stainless steel, which is generally used for HPLC flow piping, has excellent pressure resistance and corrosion resistance. However, because it is a metal, it often interacts with compounds containing phosphate groups, causing peak shape deterioration and strength degradation. In order to suppress metal adsorption, channel cleaning with phosphoric acid, addition of chelating agents, and masking with highly concentrated samples are used. However, it is difficult to obtain reproducible analysis results even with such treatments.
In this paper, we report on the use of the “Nexera XS inert” system, an ultra-high performance liquid chromatograph with a “metal-free flow path” that prevents metal from contacting the sample, and a “metal-free column” with a stainless steel column body coated with PEEK material on the inner surface. The “Nexera XS inert” system, which realizes “ultra-high performance liquid chromatography” and a “metal-free column” coated with PEEK on the inner surface of the stainless steel column body, are used to demonstrate the adsorption inhibitory effect on phosphate compounds such as nucleotides. … ( To be continued at NL website )