Symposium etc.
JSSX 25th Anniversary Symposium
October 7 (Thu.)13:40 - 17:50Room A (Large Hall)
"Towards the Next Stage of DMPK Research by Integrating Uncovered Roles of Enzymes and Transporters - Challenges for Innovative Drug Discovery and Pharmacotherapy -"
Chairs :Ken-ichi Inui (Kyoto Pharmaceutical University)
:Ikumi Tamai (Kanazawa University)MEMORY OF JSSX 25TH ANNIVERSARY
Yasushi Yamazoe (Tohoku University)
INTRODUCTION OF THIS SYMPOSIUM
Ikumi Tamai (Kanazawa University)
Chairs :Akira Tsuji (Kanazawa University)
:Toshio Teramura (Astellas Pharma Inc.)TARGETED RADIONUCLIDE THERAPY - PRACTICE OF TARGETING CONFIRMATIVE THERAPY, AN INDIVIDUALIZED IMAGE-BASED TREATMENT
Seigo Kinuya (Department of Nuclear Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University)
MOLECULAR IMAGING ESPECIALLY PET - A USEFUL TOOL FOR IN VIVO MEASUREMENTS IN DRUG DEVELOPMENT
Bengt Långström (Uppsala Univ. Depart. Biochem. and Org. Chemistry, Uppsala, Sweden)
Chairs :Tetsuya kamataki (Hokkaido University)
:Toshiya Moriwaki (Takeda Pharmaceutical Co., Ltd.) APPLICATION OF PHYSIOLOGICALLY BASED PHARMACOKINETIC(PBPK) MODELING AND CLEARANCE CONCEPT TO THE ANALYSIS OF TRANSPORTER-MEDIATED
DISTRIBUTION AND CLEARANCE OF DRUGS IN HUMAN
Yuichi Sugiyama (Graduate School of Pharmaceutical Sciences, The University of Tokyo)
HUMAN DRUG METABOLITES AND INTERACTIONS MEDIATED POLYMORPHIC DRUGMETABOLIZING ENZYMES
Hiroshi Yamazaki (Showa Pharmaceutical University)
Chairs :Takahiko Baba (Shionogi & Co., Ltd.)
:Takashi Izumi (Daiichi Sankyo Co., Ltd.) RECLINICAL STUDIES ON DRUG METABOLISM AND PHARMACOKINETICS IN STRATEGIC DRUG DISCOVERY FOR SUCCESSFUL DEVELOPMENT OF NEW DRUGS
Masato Chiba (Molecular Target Drug Discovery, Drug Discovery Research Center, TAIHO Pharmaceutical Co., Ltd.)
SCIENTIFIC PERSPECTIVE ON CYP- AND TRANSPORTER- BASED DRUG-DRUG
INTERACTIONS: IMPACT ON DRUG EXPOSURE/RESPONSE, LABELING AND CLINICAL DECISIONS
Shiew-Mei Huang (FDA)
Symposium1
October 7 (Thu.)9:00 - 11:30 Room A (Large Hall)
JSSX Symposium for the Success in Drug Development 2nd Symposium - PK/PD Based Functional Linkage for Drug Discovery and Development
Organaizers :Shinji Yamashita (Setsunan University)
:Eiichi Fuse (Kyowa Hakko Kirin Co., Ltd. Chairs :Shinji Yamashita (Setsunan University)
:Eiichi Fuse (Kyowa Hakko Kirin Co., Ltd.) PK/PD, BIOMARKER + MODEL - BASED DRUG DEVELOPMENT WHERE TO START?
Ulrich Roth (Boehringer Ingelheim Pharma GmbH & Co. KG)
MEDCHEM MEETS ADME
Atsushi Naganawa (Medicinal Chemistry Research Laboratories, Minase Research institute, Ono Pharmaceutical Co., LTD.)
ADME RESEARCH IN DRUG DEVELOPMENT OF ANTI-CANCER AGENTS
Kunihiro Yoshisue (Taiho Pharmaceutical Co., Ltd.)
FORMULATION DESIGN AND PHARMACOKINETICS CONTROL
Kazuhiro Sako (Astellas Pharma Inc.)
COOPERATION OF DMPK AND TOX FOR DISCOVERY AND DEVELOPMENT OF SAFE DRUG
Takahiko Baba (Marketing Department, Shionogi & Co.,Ltd.)
Symposium2
October 7 (Thu.)9:00 - 11:30Room B (Small Hall)
Drug Metabolism Research in Asia: Orphan P450 enzymes, Natural Products, and Human Metabolite Formations
Organizers :Hiroshi Yamazaki (Showa Pharmaceutical University)
: Yune-Fang Ueng (National Research Institute of Chinese Medicine)Chairs :Hiroshi Yamazaki (Showa Pharmaceutical University)
:Yune-Fang Ueng (National Research Institute of Chinese Medicine)ROLES OF P450 1A AND 3A ENZYMES INVOLVED IN REACTIVE METABOLITE FORMATIONS
Hiroshi Yamazaki (Showa Pharmaceutical University)
GENERATION OF HUMAN DRUG METABOLITES BY BACTERIAL CYTOCHROME P450
BM3 MUTANTS
Chul-Ho Yun (Chonnam National University)
ELUCIDATING THE FUNCTION OF ORPHAN HUMAN CYTOCHROME P450S
Zhong-Liu Wu (Chengdu Institute of Biology, Chinese Academy of Sciences)
SAFROLE AND HUMAN CYTOCHROME P450: BIOACTIVATION, INHIBITION, AND INDUCTION
Yune-Fang Ueng (National Research Institute of Chinese Medicine)
CYP3A5, GENDER, AND INTESTINAL ENZYME EXPRESSION AFFECT PHARMACOKINETICS OF NIFEDIPINE
Jin-ding Huang (National Cheng Kung University)
Symposium 3
October 8 (Fri.)9:00 - 11:30Room A (Large Hall)
Transporter as the Cause of Disease and the Target of Pharmacotherapy
Organizer :Mikihisa Takano (Hiroshima University),
:Setsuko Komuro (Dainippon Sumitomo Pharma Co.,Ltd.)
:Yoshiharu Deguchi (Teikyo University)
:Toshiharu Horie (Chiba University)
Chairs :Setsuko Komuro (Dainippon Sumitomo Pharma Co.,Ltd.)
:Toshiharu Horie (Chiba University)IDENTIFICATION OF ABCG2/BCRP AS A MAJOR CAUSE FOR GOUT
Hirotaka Matsuo (Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College)
DISCOVERY AND IDENTIFICATION OF NOVEL DRUG TARGETS BASED ON THE ANALYSIS OF THE EXPRESSION AND FUNCTION OF DISEASE-ASSOCIATED ABC TRANSPORTERS
Tsuyoshi Shuto (Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University)
NPC1L1, A PHARMACOLOGICAL TARGET OF DYSLIPIDEMIA
Tappei Takada (Department of Pharmacy, The University of Tokyo Hospital)
RESEARCH ON TRANSPORTERS IN DRUG DISCOVERY AND DEVELOPMENT
Noriko Okudaira (Daiichi Sankyo Co., Ltd.)
Symposium 4
October 8 (Fri.)9:00 - 11:30Room B (Small Hall)
Fundamentals and Prospects of UDP-glucuronyltransferase (UGT) in Drug Development
Organizers:Kan Chiba (Chiba University)
:Akira Hiratsuka(Tokyo University of Pharmacy And Life Sciences)
:Kenichiro Ogura (Tokyo University of Pharmacy and Life Sciences)
Chairs:Kan Chiba( Chiba University)
:Akira Hiratsuka(Tokyo University of Pharmacy and LifeSciences)
:Kenichiro Ogura (Tokyo University of Pharmacy and Life Sciences)NEW ASPECTS OF UDP-GLUCURONOSYLTRANSFERASE
Hiroshi Yokota (Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University)
TRANSCRIPTIONAL REGULATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE UGT1A1 GENE EXPRESSION AND THE ALTERATION IN ITS PROTEIN EXPRESSION BY INTRACELLULAR FACTORS CONTROLLING CELL PROLIFERATION
Junko Sugatani (Department of Pharmaco-Biochemistry and Global COE Program, School of Pharmaceutical Sciences, University of Shizuoka)
DEVELOPMENT OF GLUCURONIDE PREPARATION SYSTEM FOR XENOBIOTIC METABOLITES USING GENETICALLY ENGINEERED BUDDING YEAST
Shinichi Ikushiro (Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University)
PROTEIN-PROTEIN ASSOCIATION OF CYTOCHROME P450 AND UDPGLUCURONOSYLTRANSFERASE: ITS RELEVANCE TO ENZYME FUNCTION
Yuji Ishii (Graduate School of Pharmaceutical Sciences, Kyushu University)
EVALUATION OF IN VITRO GLUCURONIDATION
Miki Nakajima (Faculty of Pharmaceutical Sciences, Kanazawa University)
Forum2010
October 9 (Sat.)13:40 - 16:40Room A (Large Hall)
The Status and Future Perspective of Protein Drugs: Their Safety, Pharmacokinetics and Approval
Organizers :Hideyuki Yamada( Kyushu University)
:Takashi Izumi(Daiichi Sankyo Co., Ltd.)
Chair :Takashi Izumi(Daiichi Sankyo Co., Ltd.)
GLOBAL/DOMESTIC MARKET AND DEVELOPMENT STATUS OF BIOLOGICS
Eiji Takahara (Takeda Bio Development Center)
REGULATORY CMC ISSUES OF PROTEIN DRUGS
Koji Kawakami (Kyoto University)
Chair :Shizuo Narimatsu(Okayama University)
Quality and Safety Evaluation of Biotechnology-Derived Pharmaceuticals
Toru Kawanishi (National Institue of Health Sciences)THE IMPACT OF CLINICALPHARMACOLOGY APPROACHES IN MONOCLONAL ANTIBODY DEVELOPMENT
Kimio Terao (Chugai Pharmaceutical co.,ltd. Clinical Research Planning Dept.)
Chair :Shinsaku Naito(Otsuka Pharmaceutical Factory Inc.)
PHARMACOKINETIC STUDIES OF PROTEIN, PEPTIDE AND ANTIBODY DRUGS -REGULATIONS AND OPERATIONS-
Takuo Ogihara (Faculty of Pharmacy, Takasaki University of Health and Welfare)
CLINICAL TRIALS FOR DEVELOPMENTS OF BIOLOGIC DRUGS SUCH AS PROTEINS, PEPTIDES AND ANTIBODIES
Yuji Kumagai (Clinical Trial Center, Kitasato University East Hospital)
Summary Hideyuki Yamada (Kyushu University)
