Date:April 15 (Thu)- April 16 (Fri), 2004
Venue:Kamijo Auditorium, Showa University(Hatanodai, Shinagawa-ku, Tokyo)
Chairman of the organizing committee:Toshihiko Ikeda, Ph.D.(Sankyo Co., Ltd.)
Theme:New Technologies Enhancing Drug Discovery and Clinical Development-From Biomarker to Microdosing-
Sponsored by: JSSX

April, 15(Thu)***Title(Draft)
Takashi Kadowaki (Tokyo U.) *** Keynote lecture: Adiponectin and diabetes mellitus

Exploration of biomarker and its application
Osamu Nishimura (Shimadzu) *** Topics on proteomics
Toru Itoh (Rikaken) *** Non-targeted metabolome analysis by FT-MS−Technology in Phenomenome Discoveries−
Tomoyoshi Soga (Keio U.) *** New method for analysis of metabolome by capillary electrophoresis-mass spectrometry
Hiroshi Yamamoto (Pfizer) *** Toxicology biomarker
Noriaki Matsumoto (Showa Col. of Pharmacy) *** Clinical application of biomarkers
Kyoichi Totsuka (Tokyo Women’s Medical University) *** Time above MIC and clinical pharmacology of antibiotics
Noboru Yamamoto (National Cancer Inst.) *** Tumor markers and cancer therapy

SNPs and Toxicology
Hisakazu Ohtani (Kyushu U.) *** Potassium channel SNPs and QT prolongation
Ichiro Ieiri (Tottori U.) *** Transporter SNPs and Inter-individual variation of pharmacokinetics
Yasuhiro Maehara (International Medical Center of Japan) *** Ryanodine receptor SNPs and malignant hyperthermia
Ichiro Watanabe (Sankyo) *** GST SNPs and troglitazone hepatotoxicity

Reception

April 16 (Fri.)
Shinji Yamashita (Setsunan U.) *** Keynote lecture: Efficient ADME study−From exploratory screening to prediction of pharmacokinetics in humans

Exploratory ADME/Tox
Takayoshi Yoshikawa (Shionogi) *** Topics on exploratory ADME/Tox-1
Ichiro Naeshiro (Takeda) *** Topics on exploratory ADME/Tox-2
Masato Chiba (Banyu) *** Topics on exploratory ADME/Tox-3
To be announced Topics on exploratory ADME/Tox-4
Kazuya Maeda (Tokyo U.) *** Methods of transporter assay
Kiyoshi Nagata (Tohoku U.) *** Enzyme induction and reporter gene assay
Tadashi Hata (Sankyo) *** Substrate specificity of P450 elucidated by X-ray crystallography?

New analytical method
Dian Lee (AIM Research) *** LC-ARC-MS: A novel online sensitive system for metabolite profiling and structure elucidation

Topics on regulatory affairs
Masamitsu Watanabe (Yamatake) *** Topics on FDA-Part11
Kazuhiko Mori (National Inst. Health) *** Topics on bridging
Ian Wilding (Pharmaceutical Profiles) *** Improving the PK/BA quality of new drug candidates using human Microdosing studies