CONTENTS

Review

Analysis Methods and Recent Advances in Nonlinear Pharmacokinetics from In Vitro through In Loci to In Vivo K. YAMAOKA and Y. TAKAKURA

397

Regular Article

Effect of Polycyclic Aromatic Hydrocarbons on Generation and EOEux of Glutathione Conjugates in Primary Cultured Alveolar Epithelial Cells K. NAGAYOSHI, T. NEMOTO, S. YOKOYAMA, F. YAMASHITA and M. HASHIDA	407
Immunosuppressive Interactions among Calcium Channel Antagonists and Selected Corticosteroids and Macrolides Using Human whole Blood Lymphocytes F.-S. CHOW and W. J. JUSKO	413
Effects of NO-1886 (Ibrolipim), a Lipoprotein Lipase-Promoting Agent, on Gene Induction of Cytochrome P450s, Carboxylesterases, and Sulfotransferases in Primary Cultures of Human Hepatocytes M. NISHIMURA, T. IMAI, Y. MORIOKA, S. KURIBAYASHI, T. KAMATAKI and S. NAITO	422
Absorption and Metabolic Extraction of Diltiazem from the Perfused Rat Small Intestine T. IWAO, K. INOUE, Y. HAYASHI, H. YUASA and J. WATANABE	430
Assessment of Adverse Reactions and Pharmacokinetics of Ribavirin in Combination with Interferon a-2b in Patients with Chronic Hepatitis C M. UCHIDA, A. HAMADA, M. YAMASAKI, S. FUJIYAMA, Y. SASAKI, H. SAITO	438
Functional Characterization of Single Nucleotide Polymorphisms with Amino Acid Substitution in CYP1A2, CYP2A6, and CYP2B6 Found in the Japanese Population M. IWASAKI, Y. YOSHIMURA, S. ASAHI, K. SAITO, S. SAKAI, S. MORITA, O. TAKENAKA, T. INODA, E. KASHIYAMA, A. AOYAMA, T. NAKABAYASHI, S. OMORI, T. KUWABARA, T. IZUMI, K. NAKAMURA, K. TAKANAKA, Y. NAKAYAMA, M. TAKEUCHI, H. NAKAMURA, S. KAMETANI, Y. TERAUCHI, T. HASHIZUME, S. NAGAYAMA, T. KUME, M. ACHIRA, H. KAWAI, T. KAWASHIRO, A. NAKAMURA, Y. NAKAI, A. KAGAYAMA, T. SHIRAGA, T. NIWA, T. YOSHIMURA, J. MORITA, F. OHSAWA, M. TANI, N. OSAWA, K. IDA and K. NOGUCHI	444

SNP Communication

A Novel Variant Allele of OATP-C (SLCO1B1) Found in a Japanese Patient with Pravastatin-induced Myopathy K. MORIMOTO, T. OISHI, S. UEDA, M. UEDA, M. HOSOKAWA and K. CHIBA

SNP33 (453)