CONTENTS

Review

In Silico Approaches for Predicting ADME Properties of Drugs F. YAMASHITA and M. HASHIDA

327

Regular Article

Eisai Hyperbilirubinemic Rat (EHBR) as an Animal Model Affording High Drug- Exposure in Toxicity Studies on Organic Anions H. NABA, C. KUWAYAMA, C. KAKINUMA, S. OHNISHI and T. OGIHARA	339
Utility of a Three-Dimensional Cultured Human Skin Model as a Tool to Evaluate the Simultaneous Diffusion and Metabolism of Ethyl Nicotinate in Skin K. SUGIBAYASHI, T. HAYASHI, K. MATSUMOTO and T. HASEGAWA	352
Mechanism of L-lactic Acid Transport in L6 Skeletal Muscle Cells M. KOBAYASHI, S. ITAGAKI, T. HIRANO and K. ISEKI	363
Methotrexate-Loxoprofen Interaction: Involvement of Human Organic Anion Transporters hOAT1 and hOAT3 Y. UWAI, R. TANIGUCHI, H. MOTOHASHI, H. SAITO, M. OKUDA and K. INUI	369
Effect of Genetic Polymorphism of OATP-C (SLCO1B1) on Lipid-Lowering Response to HMG-CoA Reductase Inhibitors R. TACHIBANA-IIMORI, Y. TABARA, H. KUSUHARA, K. KOHARA, R. KAWAMOTO, J. NAKURA, K. TOKUNAGA, I. KONDO, Y. SUGIYAMA and T. MIKI	375
Statistical Evaluation of Clinical Trial Design for a Population Pharmacokinetic Study —A Case Study— S. NAKADE, A. NISHIBORI, H. OKAMOTO and S. HIGUCHI	381

Note

Effect ofWater Intake on Pharmacokinetics of Lansoprazole from Fast Disintegrating Tablet in Human Subjects K. IWASAKI, Y. ITO, N. SHIBATA, K. TAKADA, Y. SAKURAI, N. TAKAGI, S. IRIE and K. NAKAMURA

390