CONTENTS

Review

Cancer Prevention by Natural Compounds H. TSUDA, Y. OHSHIMA, H. NOMOTO, K. FUJITA, E. MATSUDA, M. IIGO, N. TAKASUKA and M. A. MOORE

245

Note

Transporter mRNA Expression in a Conditionally Immortalized Rat Small Intestine Epithelial Cell Line (TR-SIE) K. HOSOYA, M. TOMI, M. TAKAYAMA, Y. KOMOKATA, D. NAKAI, T. TOKUI, K. NISHIMURA, M. UEDA, M. OBINATA, S. HORI, S. OHTSUKI, G. L. AMIDON and T. TERASAKI

264

Regular Article

Tolbutamide Uptake Via pH- and Membrane-potential-dependent Transport Mechanism in Mouse Brain Capillary Endothelial Cell Line N. KOYABU, H. TAKANAGA, H. MATSUO, M. NAITO, T. TSURUO, H. OHTANI and Y. SAWADA	270
Effects of Continuous Ingestion of Green Tea or Grape Seed Extracts on the Pharmacokinetics of Midazolam M. NISHIKAWA, N. ARIYOSHI, A. KOTANI, I. ISHII, H. NAKAMURA, H. NAKASA, M. IDA, H. NAKAMURA, N. KIMURA, M. KIMURA, A. HASEGAWA, F. KUSU, S. OHMORI, K. NAKAZAWA and M. KITADA	280
Enhancement of Acetaminophen Cytotoxicity in Selenium-binding Protein-overexpressed COS-1 Cells T. ISHIDA, M. ABE, K. OGURI and H. YAMADA	290
Kinetic Studies of Covalent Binding between N-acetyl-L-cysteine and Human Serum Albumin Through a Mixed-disulˆde Using an N-methylpyridinium Polymer-based Column D. HARADA, M. ANRAKU, H. FUKUDA, S. NAITO, K. HARADA, A. SUENAGA and M. OTAGIRI	297

Short Communication

Genotyping of Single Nucleotide Polymorphisms (SNPs) Influencing Drug Response by Competitive Allele-specific Short Oligonucleotide Hybridization (CASSOH) with Immunochromatographic Strip M. HIRATSUKA, A. EBISAWA, Y. MATSUBARA, S. KURE, Y. KONNO, T. SASAKI and M. MIZUGAKI

303

SNP Communication

Seven Novel Single Nucleotide Polymorphisms in the Human SLC22A1 Gene Encoding Organic Cation Transporter 1 (OCT1) M. ITODA, Y. SAITO, K. MAEKAWA, H. HICHIYA, K. KOMAMURA, S. KAMAKURA, M. KITAKAZE, H. TOMOIKE, K. UENO, S. OZAWA and J. SAWADA	SNP14 (308)
Novel Nonsynonymous Single Nucleotide Polymorphisms in the CYP2D6 Gene A. SOYAMA, T. KUBO, A. MIYAJIMA, Y. SAITO, K. SHISEKI, K. KOMAMURA, K. UENO, S. KAMAKURA, M. KITAKAZE, H. TOMOIKE, S. OZAWA and J. SAWADA	SNP19 (313)
Genetic Variations of the AHR Gene Encoding Aryl Hydrocarbon Receptor in a Japanese Population H. FUKUSHIMA-UESAKA, K. SAI, K. MAEKAWA, S. KOYANO, N. KANIWA, S. OZAWA, M. KAWAMOTO, N. KAMATANI, K. KOMAMURA, S. KAMAKURA, M. KITAKAZE, H. TOMOIKE, K. UENO, H. MINAMI, A. OHTSU, K. SHIRAO, T. YOSHIDA, N. SAIJO, Y. SAITO and J. SAWADA	SNP26 (320)