CONTENTS

Review

Molecular Aspects of Renal Handling of Aminoglycosides and Strategies for Preventing the Nephrotoxicity J. NAGAI and M. TAKANO	159
The Organic Anion Transporter (OATP) Family T. MIKKAICHI, T. SUZUKI, M. TANEMOTO, S. ITO and T. ABE	171

Regular Article

Functional Regions of Organic CationWCarnitine Transporter OCTN2 (SLC22A5): Roles in Carnitine Recognition A. INANO, Y. SAI, Y. KATO, I. TAMAI, M. ISHIGURO and A. TSUJI	180
Effect of Experimental Acute Renal and Hepatic Failure on Absorption of Tacrolimus in Rat Small Intestine S. TAMURA, A. OHIKE, Y. TOKUNAGA, R. IBUKI, G. L. AMIDON, H. SEZAKI and S. YAMASHITA	190
Regulation of Drug Absorption from Small Intestine by Enteric Nervous System I: a Poorly Absorbable Drug Via Passive Diffusion K. HIGAKI, M. SONE, K. OGAWARA and T. KIMURA	198
Pharmacokinetic Modeling of Species-dependent Enhanced Bioavailability of Trifluorothymidine by Thymidine Phosphorylase Inhibitor H. TSUCHIYA, K. KUWATA, S. NAGAYAMA, K. YAMASHITA, H. KAMIYA and H. HARASHIMA	206
Regioselective Monosulfation and Disulfation of the Phytoestrogens Daidzein and Genistein by Human Liver Sulfotransferases H. NAKANO, K. OGURA, E. TAKAHASHI, T. HARADA, T. NISHIYAMA, K. MURO, A. HIRATSUKA, S. KADOTA and T. WATABE	216
Evaluation of Fast Disintegrating Lansoprazole Tablet in Human Subjects K. IWASAKI, Y. YOSHIKAWA, N. SHIBATA, K. TAKADA, Y. SAKURAI, N. TAKAGI, S. IRIE and K. NAKAMURA	227

SNP Communication

A Novel Single Nucleotide Polymorphism (SNP) of the CYP2C19 Gene in a Japanese Subject with Lowered Capacity of Mephobarbital 4'-Hydroxylation J. MORITA, K. KOBAYASHI, A. WANIBUCHI, M. KIMURA, S. IRIE, T. ISHIZAKI, and K. CHIBA	SNP5 (236)
Fourteen Novel Single Nucleotide Polymorphisms in the SLC22A2 Gene Encoding Human Organic Cation Transporter (OCT2) H. FUKUSHIMA-UESAKA, K. MAEKAWA, S. OZAWA, K. KOMAMURA, K. UENO, M. SHIBAKAWA, S. KAMAKURA, M. KITAKAZE, H. TOMOIKE, Y. SAITO and J. SAWADA	SNP8 (239)