CONTENTS

Review

Ethnic Differences in Genetic Polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1WABCB1 S. OZAWA, A. SOYAMA, M. SAEKI, H. FUKUSHIMA-UESAKA, M. ITODA, S. KOYANO, K. SAI, Y. OHNO, Y. SAITO and J. SAWADA

83

Regular Article

Effect of Neonatal Exposure of 17b-Estradiol and Tamoxifen on Hepatic CYP3A Activity at Developmental Periods in Rats T. MURAKAMI, A. SATO, M. INATANI, H. SAKURAI, R. YUMOTO, J. NAGAI and M. TAKANO	96
Differences in Transactivation between Rat CYP3A1 and Human CYP3A4 Genes by Human Pregnane X Receptor T. TAKADA, M. OGINO, M. MIYATA, M. SHIMADA, K. NAGATA and Y. YAMAZOE	103
Human CYP4B1 Gene in the Japanese Population Analyzed by Denaturing HPLC M. HIRATSUKA, H. NOZAWA, Y. KONNO, T. SAITO, S. KONNO and M. MIZUGAKI	114
CYP3A5 Contributes Significantly to CYP3A-mediated Drug Oxidations in Liver Microsomes from Japanese Subjects S. YAMAORI, H. YAMAZAKI, S. IWANO, K. KIYOTANI, K. MATSUMURA, G. HONDA, K. NAKAGAWA, T. ISHIZAKI and T. KAMATAKI	120

Note

Factors Affecting Glucuronidation Activity in Caco-2 Cells T. MIZUMA, R. MOMOTA, M. HAGA and M. HAYASHI	130
Tissue-specific mRNA Expression Profiles of Human Nuclear Receptor Subfamilies M. NISHIMURA, S. NAITO and T. YOKOI	135
Comparison of the Disposition Behavior of Organic anions in an Animal Model for Wilson's Disease (Long-Evans Cinnamon rats) with that in Normal Long-Evans Agouti rats S. ITAGAKI, M. SUGAWARA, M. KOBAYASHI, K. MIYAZAKI, T. HIRANO and K. ISEKI	150

SNP Communication

Three Novel Single Nucleotide Polymorphisms (SNPs) of the CYP2B6 Gene in Japanese Individuals M. HIRATSUKA, Y. HINAI, Y. KONNO, H. NOZAWA, S. KONNO and M. MIZUGAKI

SNP1 (155)