DMPK Volume 19, Number 1, 2004

CONTENTS

Review

Functional Evaluation of ABCB1 (P-Glycoprotein) Polymorphisms: High-Speed Screening and Structure-Activity Relationship Analyses
T. ISHIKAWA, H. HIRANO, Y. ONISHI, A. SAKURAI and S. TARUI

1

Regular Article

Pharmacokinetic Comparison of an Angiotensin II Receptor Antagonist, Telmisartan, in Japanese and Western Hypertensive Patients Using Population Pharmacokinetic Method
S. TATAMI, N. YAMAMURA, A. SARASHINA, C.-L. YONG, T. IGARASHI and Y. TANIGAWARA

15

Relationship between Pharmacokinetic Parameters and Occurrence of Adverse Events in Clinical Trials Performed in Europe and United States for an Angiotensin II Receptor Antagonist, Telmisartan
S. TATAMI, A. SARASHINA, N. YAMAMURA, T. IGARASHI and Y. TANIGAWARA

24

Lipopolysaccharide Transport System across Colonic Epithelial Cells in Normal and Infective Rat
M. TOMITA, R. OHKUBO, and M. HAYASHI

33

Decreased Expression of Glucose and Peptide Transporters in Rat Remnant Kidney
N. NAKAMURA, S. MASUDA, K. TAKAHASHI, H. SAITO, M. OKUDA and K. INUI

41

Transepithelial Permeation of Tolbutamide across the Human Intestinal Cell Line, Caco-2
N. NISHIMURA, K. NAORA, T. UEMURA, H. HIRANO and K. IWAMOTO

48

Utility of Microtiter Plate Assays for Human Cytochrome P450 Inhibition Studies in Drug Discovery: Application of Simple Method for Detecting Quasi-irreversible and Irreversible Inhibitors
Y. NARITOMI, Y. TERAMURA, S. TERASHITA and A. KAGAYAMA

55
The Effects of Emulsifying Agents on Disposition of Lipid-Soluble Drugs Included in Fat Emulsion
Y. SUZUKI, Y. MASUMITSU, K. OKUDAIRA and M. HAYASHI

62
Protective Effect of Inactive Ingredients against Nephrotoxicity of Vancomycin Hydrochloride in Rats
N. HODOSHIMA, Y. NAKANO, M. IZUMI, N. MITOMI, Y. NAKAMURA, M. AOKI, A. GYOBU, S. SHIBASAKI, and T. KUROSAWA

68
Proapoptotic Effect of a Dietary Supplement: Water Soluble Chitosan Activates Caspase-8 and Modulating Death Receptor Expression
H. TAKIMOTO, M. HASEGAWA, K. YAGI, T. NAKAMURA, T. SAKAEDA and M. HIRAI

76