CONTENTS

Review

CYP2D in the Brain Yoshihiko FUNAE, Wataru KISHIMOTO, Toshio CHO, Toshiro NIWA, and Toyoko HIROI

337

Regular Article

Estimation of Bioavailability of Salmon Calcitonin from the Hypocalcemic EŠect in Rats (I): Pharmacokinetic-Pharmacodynamic Modeling Based on the Endogenous Ca Regulatory System Makoto MIYAZAKI, Susumu NAKADE, Kazunori IWANAGA, Kazuhiro MORIMOTO and Masao KAKEMI	350
Estimation of Bioavailability of Salmon Calcitonin from the Hypocalcemic EŠect in Rats (II): EŠect of Protease Inhibitor on the Pharmacokinetic-Pharmacodynamic Relationship after Intranasal Administration Makoto MIYAZAKI, Susumu NAKADE, Kazunori IWANAGA, Kazuhiro MORIMOTO and Masao KAKEMI	358
The Intestinal First-pass Metabolism of Substrates of CYP3A4 and P-glycoprotein —Quantitative Analysis Based on Information from the Literature Motohiro KATO, Koji CHIBA, Akihiro HISAKA, Michi ISHIGAMI, Makoto KAYAMA, Naomi MIZUNO, Yoshinori NAGATA, Susumu TAKAKUWA, Yuko TSUKAMOTO, Kaoru UEDA, Hiroyuki KUSUHARA, Kiyomi ITO and Yuichi SUGIYAMA	365
Novel Organic Nitrate Prodrug 4(R)-N-(2-Nitroxyethyl)-2-Oxothiazolidine-4-Carboxamide (RS-7897) Serves as a Xenobiotic Substrate for Pyroglutamyl Aminopeptidase I in Dogs Koji ABE, Makiko YAMADA, Toshio TERAO, Hiroshi MIZUNO, Yuko MATSUOKA, Ryosuke YORIKANE, Taro TOKUI and Toshihiko IKEDA	373
Involvement of Multiple Transport Systems in the Disposition of an Active Metabolite of a Prodrug-type New Quinolone Antibiotic, Pruli‰oxacin Yukihiro YAGI, Sachiyo SHIBUTANI, Naoko HODOSHIMA, Kazuya ISHIWATA, Noriko OKUDAIRA, Qing LI, Yoshimichi SAI, Yukio KATO and Akira TSUJI	381
New SRM Data Dependent Exclusion (MS)n Measurement for Structural Determination of Drug Metabolites Using LCWESIWIon Trap MS Zenzaburo TOZUKA, Hayato KANEKO, Toshifumi SHIRAGA, Manabu BEPPU, Toshiro NIWA, Akio KAWAMURA and Akira KAGAYAMA	390

Note

Comparative Study of Flux of FITC-labeled Dextran 4000 on Normal (iso)- and Hyperosmolarity in Basal Side in Caco-2 Cell Monolayers Rie OHKUBO, Mikio TOMITA, Yoshiyuki HOTTA, Mayuko NAGIRA and Masahiro HAYASHI

404

Short Communication

Decreased Function of Genetic Variants, Pro283Leu and Arg287Gly, in Human Organic Cation Transporter hOCT1 Ayako TAKEUCHI, Hideyuki MOTOHASHI, Masahiro OKUDA and Ken-ichi INUI

409

SNP Communication

Twenty-six Novel Single Nucleotide Polymorphisms and their Frequencies of the NR1I3 (CAR) Gene in a Japanese Population Shinobu IKEDA, Kouichi KUROSE, Shogo OZAWA, Kimie SAI, Ryuichi HASEGAWA, Kazuo KOMAMURA, Kazuyuki UENO, Shiro KAMAKURA, Masafumi KITAKAZE, Hitonobu TOMOIKE, Toshiharu NAKAJIMA, Kenji MATSUMOTO, Hirohisa SAITO, Yu-ichi GOTO, Hideo KIMURA, Masaaki KATOH, Kenji SUGAI, Narihiro MINAMI, Kuniaki SHIRAO, Tomohide TAMURA, Noboru YAMAMOTO, Hironobu MINAMI, Atsushi OHTSU, Teruhiko YOSHIDA, Nagahiro SAIJO, Yoshiro SAITO and Jun-ichi SAWADA

SNP38 (413)