CONTENTS

Review

Are Novel Scavenger-Like Receptors Involved in the Hepatic Uptake of Heparin? Hiroaki YUASA and Jun WATANABE

273

Regular Article

In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations Catalyzed by Human Cytochrome P450 Enzymes: A Comparison with SKF-525A and Ketoconazole Chie EMOTO, Shigeo MURASE, Yasufusa SAWADA, Barry C. JONES and Kazuhide IWASAKI	287
Application of the PKCYP Test to Predict Caffeine Clearance Mediated by CYP1A2 in a Rat Acute Liver Injury Model Noriko KOSE (nee MATSUNAGA), Minae ISAWA, Junko KIZU, Norio MIYAZAKI, Akira TAKANAKA and Emi NAKASHIMA	296
The Contribution of Cytochrome P450 to the Metabolism of Tegafur in Human Liver Jiro KAJITA, Eiichi FUSE, Takashi KUWABARA and Hiroyuki KOBAYASHI	303
Blood-Brain Permeability of [3H]-(3-methyl-His2)Thyrotropin-releasing Hormone (MeTRH) in Mice: Effects of TRH and its Analogues Akihiko URAYAMA, Shizuo YAMADA, Yuki OHMORI, Yoshiharu DEGUCHI, Shinya UCHIDA and Ryohei KIMURA	310
Distribution Characteristics of Grepafloxacin, a Fluoroquinolone Antibiotic, in Lung Epithelial Lining Fluid and Alveolar Macrophage Yoshiharu DEGUCHI, Jin SUN, Yoshihiko TAUCHI, Shigeko SAKAI and Kazuhiro MORIMOTO	319

SNP Communication

Twelve Novel Single Nucleotide Polymorphisms in the CES2 Gene Encoding Human Carboxylesterase 2 (hCE-2) Su-Ryang KIM, Takahiro NAKAMURA, Yoshiro SAITO, Kimie SAI, Toshiharu NAKAJIMA, Hirohisa SAITO, Kuniaki SHIRAO, Hironobu MINAMI, Atsushi OHTSU, Teruhiko YOSHIDA, Nagahiro SAIJO, Shogo OZAWA and Jun-ichi SAWADA	SNP29 (327)
Two Novel Single Nucleotide Polymorphisms (SNPs) of the FMO3 Gene in Japanese Masaki FUJIEDA, Hiroshi YAMAZAKI, Masahiro TOGASHI, Tetsuya SAITO and Tetsuya KAMATAKI	SNP35 (333)