DMPK Volume 18, Number 4, 2003

CONTENTS

Review

Development of Novel Technology of DDS for Gene Therapy
Shinsaku NAKAGAWA and Tadanori MAYUMI

223

Regular Article

Analysis of Hepatic Disposition of Native and Galactosylated Polyethylenimine Complexed with Plasmid DNA in Perfused Rat Liver
Shintaro FUMOTO, Shigeru KAWAKAMI, Masako ISHIZUKA, Makiya NISHIKAWA, Fumiyoshi YAMASHITA and Mitsuru HASHIDA

230

Mechanism of Active Secretion of Phenolsulfonphthalein in the Liver via Mrp2 (abcc2), an Organic Anion Transporter
Shirou ITAGAKI, Mitsuru SUGAWARA, Michiya KOBAYASHI, Katsumi MIYAZAKI and Ken ISEKI

238

Uptake Mechanism of Pitavastatin, a New Inhibitor of HMGCoA Reductase, in Rat Hepatocytes
Syunsuke SHIMADA, Hideki FUJINO, Takashi MORIKAWA, Matsuko MORIYASU and Junji KOJIMA

245

Separate Assessment of Intestinal and Hepatic Firstpass Eects Using a Rat Model with Double Cannulation of the Portal and Jugular Veins
Tsuyoshi MURAKAMI, Machiko NAKANISHI, Takeo YOSHIMORI, Noboru OKAMURA, Ryo NORIKURA and Kenji MIZOJIRI

252

Evaluation of Percutaneous Absorption of Midazolam by Terpenes
Yusuke OTA, Akinobu HAMADA, Masahiro NAKANO, and Hideyuki SAITO

261

SNP Communication

CYP3A4*18: It is not Rare Allele in Japanese Population
Takehito YAMAMOTO, Nobue NAGAFUCHI, Takeshi OZEKI, Takahiro KUBOTA, Hiroshi ISHIKAWA, Seishi OGAWA, Yasuhiko YAMADA, Hisamaru HIRAI and Tatsuji IGA

SNP24 (267)

Two Novel Haplotypes of CYP2D6 Gene in a Japanese Population
Hiroshi YAMAZAKI, Kazuma KIYOTANI, Satoshi TSUBUKO, Masayuki MATSUNAGA, Masaki FUJIEDA, Tetsuya SAITO, Jun MIURA, Shinichi KOBAYASHI, and Tetsuya KAMATAKI

SNP26 (269)