CONTENTS

Review

Drug Metabolism in Peroxisomes: Involvement of Peroxisomal β-Oxidation System in the Oxidative Chain-shortening of Xenobiotic Acyl Compounds Tetsuya SUGA

155

Regular Article

Production of Inhibitory Polyclonal Antibodies against Cytochrome P450s Poh-Sing NG, Susumu IMAOKA, Toyoko HIROI, Mayuko OSADA, Toshio NIWA, Tetsuya KAMATAKI and Yoshihiko FUNAE	163
Metabolism of N,N-Dipropyl-2-[4-Methoxy-3-(2-Phenyl-Ethoxy)-Phenyl]-Ethyl-Amine-Monohydrochloride (NE-100), A Novel Sigma Ligand: Contribution of Cytochrome P450 Forms Involved in the Formation of Individual Metabolites in Human Liver and Small Intestine Takahito YAMAMOTO, Naoko HAGIMA, Misako FUKASAWA, Jun-ichi YAMAGUCHI, Masato NAKAMURA, Yoshiro KOHNO, Kiyoshi NAGATA and Yasushi YAMAZOE	173
Inhibitory Eects of Basic Drugs on the Sodium-Dependent Transport of L-Alanine via System B0 in the Small Intestine Mitsuru SUGAWARA, Masaya KATO, Mayumi KITAKUBO, Yoh TAKEKUMA, Vadivel GANAPATHY and Katsumi MIYAZAKI	186
Expression and Functional Characterization of Human ABC Transporter ABCG2 Variants in Insect Cells Toshihisa ISHIKAWA, Shiho KASAMATSU, Yuko HAGIWARA, Hideyuki MITOMO, Ryo KATO and Yasuhiro SUMINO	194
Population Pharmacokinetics of an Angiotensin II Receptor Antagonist, Telmisartan, in Healthy Volunteers and Hypertensive Patients Shinji TATAMI, Akiko SARASHINA, Norio YAMAMURA, Takashi IGARASHI and Yusuke TANIGAWARA	203

SNP Communication

Eight Novel Single Nucleotide Polymorphisms in ABCG2BCRP in Japanese Cancer Patients Administered Irinotacan Masaya ITODA, Yoshiro SAITO, Kuniaki SHIRAO, Hironobu MINAMI, Atsushi OHTSU, Teruhiko YOSHIDA, Nagahiro SAIJO, Hiroshi SUZUKI, Yuichi SUGIYAMA, Shogo OZAWA and Jun-ichi SAWADA	SNP14 (212)
Novel Nonsynonymous Polymorphisms of the CYP1A1 Gene in Japanese Tetsuya SAITO, Mari EGASHIRA, Kazuma KIYOTANI, Masaki FUJIEDA, Hiroshi YAMAZAKI, Chikako KIYOHARA, Hideo KUNITOH and Tetsuya KAMATAKI	SNP20 (218)