CYP Isoforms Involved in the Metabolism of Clarithromycin in vitro: Comparison between the Identification from Disappearance Rate and that from Formation Rate of Metabolites
Akio SUZUKI, Izumi IIDA, Mitsuyo HIROTA, Masayuki AKIMOTO, Shohei HIGUCHI, Toshio SUWA, Masayoshi TANI, Takashi ISHIZAKI and Kan CHIBA

104

Pharmacokinetic Interactions between Cyclosporine and Protease Inhibitors in HIV+ Subjects
Lynda FRASSETTO, Thien THAI, Anjana M AGGARWAL, Patricia BUCHER, Wolfgang JACOBSEN, Uwe CHRISTIANS, Leslie Z BENET and Leslie C FLOREN

114

Evaluation of Methods for Predicting Drug-drug Interactions by Monte Carlo Simulation
Motohiro KATO, Tatsuhiko TACHIBANA, Kiyomi ITO and Yuichi SUGIYAMA

121

Substrate Dependent Inhibition Profiles of Fourteen Drugs on CYP3A4 Activity Measured by A High Throughput LCMS/MS Method with Four Probe Drugs, Midazolam, Testosterone, Nifedipine and Terfenadine
Jagdish K. RACHA, Z. Sylvia ZHAO, Nicholas OLEJNIK, Nadine WARNER, Rebecca CHAN, David MOORE and Hiroko SATOH

128

Note

Assessment of Tear Concentrations on Therapeutic Drug Monitoring. III. Determination of Theophylline in Tears by Gas Chromatography/Mass Spectrometry with Electron Ionization Mode
Masaharu NAKAJIMA, Shinji SATO, Susumu YAMATO, Kenji SHIMADA, Shuji KITAGAWA, Akira HONDA, Jiro MIYAMOTO, Harunobu HIRANO, Mitsuyuki SUZUKI and Hiroshi MIYAZAKI

139

SNP Communication

Three Novel Single Nucleotide Polymorphisms in UGT1A9
Mayumi SAEKI, Yoshiro SAITO, Hideto JINNO, Kimie SAI, Kazuo KOMAMURA, Kazuyuki UENO, Shiro KAMAKURA, Masafumi KITAKAZE, Kuniaki SHIRAO, Hironobu MINAMI, Atsushi OHTSU, Teruhiko YOSHIDA, Nagahiro SAIJO, Shogo OZAWA and Jun-ichi SAWADA

SNP6 (146)

Five Novel Single Nucleotide Polymorphisms in the EPHX1 Gene Encoding Microsomal Epoxide Hydrolase
Kisho SHISEKI, Masaya ITODA, Yoshiro SAITO, Yukiko NAKAJIMA, Keiko MAEKAWA, Hideo KIMURA, Yu-ichi GOTO, Osamu SAITOH, Masaaki KATOH, Teiichi OHNUMA, Mitsuru KAWAI, Kenji SUGAI, Taisuke OHTSUKI, Chieko SUZUKI, Narihiro MINAMI, Shogo OZAWA and Jun-ichi SAWADA

SNP10 (150)

CONTENTS

Review

Regular Article

Note

SNP Communication

CYP Isoforms Involved in the Metabolism of Clarithromycin in vitro: Comparison between the Identification from Disappearance Rate and that from Formation Rate of Metabolites Akio SUZUKI, Izumi IIDA, Mitsuyo HIROTA, Masayuki AKIMOTO, Shohei HIGUCHI, Toshio SUWA, Masayoshi TANI, Takashi ISHIZAKI and Kan CHIBA	104
Pharmacokinetic Interactions between Cyclosporine and Protease Inhibitors in HIV+ Subjects Lynda FRASSETTO, Thien THAI, Anjana M AGGARWAL, Patricia BUCHER, Wolfgang JACOBSEN, Uwe CHRISTIANS, Leslie Z BENET and Leslie C FLOREN	114
Evaluation of Methods for Predicting Drug-drug Interactions by Monte Carlo Simulation Motohiro KATO, Tatsuhiko TACHIBANA, Kiyomi ITO and Yuichi SUGIYAMA	121
Substrate Dependent Inhibition Profiles of Fourteen Drugs on CYP3A4 Activity Measured by A High Throughput LCMS/MS Method with Four Probe Drugs, Midazolam, Testosterone, Nifedipine and Terfenadine Jagdish K. RACHA, Z. Sylvia ZHAO, Nicholas OLEJNIK, Nadine WARNER, Rebecca CHAN, David MOORE and Hiroko SATOH	128

Three Novel Single Nucleotide Polymorphisms in UGT1A9 Mayumi SAEKI, Yoshiro SAITO, Hideto JINNO, Kimie SAI, Kazuo KOMAMURA, Kazuyuki UENO, Shiro KAMAKURA, Masafumi KITAKAZE, Kuniaki SHIRAO, Hironobu MINAMI, Atsushi OHTSU, Teruhiko YOSHIDA, Nagahiro SAIJO, Shogo OZAWA and Jun-ichi SAWADA	SNP6 (146)
Five Novel Single Nucleotide Polymorphisms in the EPHX1 Gene Encoding Microsomal Epoxide Hydrolase Kisho SHISEKI, Masaya ITODA, Yoshiro SAITO, Yukiko NAKAJIMA, Keiko MAEKAWA, Hideo KIMURA, Yu-ichi GOTO, Osamu SAITOH, Masaaki KATOH, Teiichi OHNUMA, Mitsuru KAWAI, Kenji SUGAI, Taisuke OHTSUKI, Chieko SUZUKI, Narihiro MINAMI, Shogo OZAWA and Jun-ichi SAWADA	SNP10 (150)