CONTENTS

Review

Safety Evaluation and Drug Development based on Biological Fate of Drugs --Efforts Made to Overcome Drug Interaction in Drug Development-- Takashi MATSUBARA	379
Application of In Vivo Brain Microdialysis to the Study of Blood-Brain Barrier Transport of Drugs Yoshiharu DEGUCHI	395

Regular Articles

New Methods to Evaluate Intestinal Drug Absorption Mediated by Oligopeptide Transporter from In vitro Study using Caco-2 Cells Shinji YAMASHITA, Emiko HATTORI, Aiko SHIMADA, Yoriko ENDOH, Yukako YAMAZAKI, Makoto KATAOKA, Toshiyasu SAKANE and Hitoshi SEZAKI	408
Evidence for Singlet Oxygen Involvement in Rat and Human Cytochrome P450-dependent Substrate Oxidations Hiroyuki YASUI, Kazuko DEO, Yuko OGURA, Hiromi YOSHIDA, Toshifumi SHIRAGA, Akira KAGAYAMA and Hiromu SAKURAI	416
Species Difference in Nisoldipine Oxidation Activity in the Small Intestine Hiroshi KOMURA, Motoko YASUDA, Nagahiro H. YOSHIDA and Yuichi SUGIYAMA	427
Application of Microtiter Plate Assay to Evaluate Inhibitory Effects of Various Compounds on Nine Cytochrome P450 Isoforms and to Estimate their Inhibition Patterns Takahito YAMAMOTO, Akio SUZUKI and Yoshiro KOHNO	437
Metabolic Fate of Pitavastatin, a New Inhibitor of HMG-CoA Reductase--Effect of cMOAT Deficiency on Hepatobiliary Excretion in Rats and of mdr1a/b Gene Disruption on Tissue Distribution in Mice Hideki FUJINO, Iwao YAMADA, Syunsuke SHIMADA and Junji KOJIMA	449
Formation of a Structurally Novel, Serial Diglucuronide of 4-Hydroxybiphenyl by Further Glucuronidation of a Monoglucuronide in Dog Liver Microsomes Takahiro MURAI, Fujiko TSURUTA, Toshio TERAO, Toshihiko IKEDA and Haruo IWABUCHI	457
Effects of St John's Wort and Hypericin on Cytotoxicity of Anticancer Drugs. Atsushi WADA, Toshiyuki SAKAEDA, Kohji TAKARA, Midori HIRAI, Takashi KIMURA, Nobuko OHMOTO, Jie ZHOU, Tsutomu NAKAMURA, Hironao KOBAYASHI, Noboru OKAMURA, Tatsurou YAGAMI and Katsuhiko OKUMURA	467

SNP Communications

Novel single nucleotide polymorphisms in the CYP2D6 gene associated with CYP2D6*2 and/or CYP2D6*10 alleles Akiko SOYAMA, Yoshiro SAITO, Kazuo KOMAMURA, Kazuyuki UENO, Shiro KAMAKURA, Shogo OZAWA and Jun-ichi SAWADA	SNP11 (475)
Polymorphism of MDR1 Gene in Healthy Japanese Subjects: A Novel SNP with an Amino Acid Substitution (Glu108Lys) Tomohiro HONDA, Yukihiko DAN, Noriko KOYABU, Ichiro IEIRI, Kenji OTSUBO, Shun HIGUCHI, Hisakazu OHTANI and Yasufumi SAWADA	SNP15 (479)
Twenty One Novel Single Nucleotide Polymorphisms (SNPs) of the CYP2A6 Gene in Japanese and Caucasians Kazuma KIYOTANI, Masaki FUJIEDA, Hiroshi YAMAZAKI, Tsutomu SHIMADA, F. Peter GUENGERICH, Andrew PARKINSON, Kazuko NAKAGAWA, Takashi ISHIZAKI, and Tetsuya KAMATAKI	SNP18 (482)
Three novel single nucleotide polymorphisms in UGT1A10 Mayumi SAEKI, Shogo OZAWA, Yoshiro SAITO, Hideto JINNO, Tetsuya HAMAGUCHI, Hiroshi NOKIHARA, Yasuhiro SHIMADA, Hideo KUNITOH, Noboru YAMAMOTO, Yuichiro OHE, Yasuhide YAMADA, Kuniaki SHIRAO, Manabu MUTO, Kiyomi MERA, Koichi GOTO, Hironobu OHMATSU, Kaoru KUBOTA, Seiji NIHO, Ryutaro KAKINUMA, Hironobu MINAMI, Atsushi OHTSU, Teruhiko YOSHIDA, Nagahiro SAIJO and Jun-ichi SAWADA	SNP24 (488)

Instructions to Authors

(1)