CONTENTS

Review

Genetic Polymorphism of Human Cytochrome P450 Involved in Drug Metabolism [Color vesion (pdf format) of figures] Kiyoshi NAGATA and Yasushi YAMAZOE

167

Regular Articles

Simultaneous Assessment of the In Vivo Amount of CYP1A2 and CYP3A2 by the PKCYP-test Using Theophylline in Rats Noriko MATSUNAGA, Miyoko HAYASHI, Keiko YAMAMOTO, Taeko NISHIJIMA, Junko KIZU, Kazuyo NISHIHARA, Akira TAKANAKA, Akinobu MORIKAWA and Emi NAKASHIMA	190
Metabolism of Selegiline Hydrochloride, a Selective Monoamine B-type Inhibitor, in Human Liver Microsomes Takahiro KAMADA, Toshio CHOW, Toyoko HIROI, Susumu IMAOKA, Kazuhiko MORIMOTO, Hironori OHDE and Yoshihiko FUNAE	199
A Mutation in the Flavin-containing Monooxygenase 3 Gene and its Effects on Catalytic Activity for N-oxidation of Trimethylamine In Vitro Megumi KUBOTA, Yoko NAKAMOTO, Kazuo NAKAYAMA, Pailin UJJIN, Soisungwan SATARUG, Taisei MUSHIRODA, Tsuyoshi YOKOI, Masato FUNAYAMA and Tetsuya KAMATAKI	207
Studies on the Metabolic Fate of M17055, a Novel Diuretic (5): Pharmacokinetics and Pharmacodynamics of Unchanged Drug in Rat and Dog After Intravenous Administration of M17055 Hiroyuki NAKAJIMA, Hiroyasu NABA, Takeshi NAKANISHI, Kiyohiko NAKAI, Takanori WATANABE, Keiichi IDA and Nobuo OHZAWA	214
Sulfation of Environmental Estrogens by Cytosolic Human Sulfotransferases Takahito NISHIYAMA, Kenichiro OGURA, Hiroaki NAKANO, Teppei KAKU, Eriko TAKAHASHI, Yasunari OHKUBO, Koji SEKINE, Akira HIRATSUKA Shigetoshi KADOTA and Tadashi WATABE	221
Identification of Inhibitory Component in Cinnamon --O-Methoxycinnamaldehyde Inhibits CYP1A2 and CYP2E1-- Atsushi HASEGAWA, Masaki YOSHINO, Hiroyoshi NAKAMURA, Itsuko ISHII, Toshiko WATANABE, Masahiro KIUCHI, Tsutomu ISHIKAWA, Shigeru OHMORI and Mitsukazu KITADA	229
Muscle Distribution of Antimicrobial Agents after a Single Intravenous Administration to Rats Harumi ARAKI, Naoko OGAKE, Reiko TSUNEDA, Shinzaburo MINAMI, Yasuo WATANABE, Ikumi TAMAI and Akira TSUJI	237
Interaction of Endogenous Compounds in Human and Rat Urine with P-glycoprotein Teruo MURAKAMI, Takeshi FUKUDA, Ryoko YUMOTO, Junya NAGAI, Taiju KURAMOTO and Mikihisa TAKANO	245

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