CONTENTS

Review

Drug Transporters: Their Role and Importance in the Selection and Development of New Drugs N. MIZUNO and Y. SUGIYAMA

93

Regular Articles

Contribution of CYP4A8 to the Formation of 20-Hydroxyeicosatetraenoic Acid from Arachidonic Acid in Rat Kidney Y. YAMAGUCHI, S. KIRITA, H. HASEGAWA, J. AOYAMA, S. IMAOKA, S. MINAMIYAMA, Y. FUNAE, T. BABA and T. MATSUBARA	109
Molecular Cloning of Monkey CYP2C43 cDNA and Expression in Yeast T. MATSUNAGA, S. OHMORI, M. ISHIDA, Y. SAKAMOTO, H. NAKASA and M. KITADA	117
Rat Renal Organic Anion Transporter rOAT1 Mediates Transport of Urinary-Excreted Cephalosporins, but not of Biliary-Excreted Cefoperazone Y. UWAI, H. SAITO and K. INUI	125
Does ABCG2 Need a Heterodimer Partner ? Expression and Functional Evaluation of ABCG2 (Arg 482) M. YOSHIKAWA, S. KASAMATSU, M. YASUNAGA, G. WANG, Y. IKEGAMI, H. YOSHIDA, S. TARUI, H. YABUUCHI and T. ISHIKAWA	130
Effect of Co-administration of Cationic Macromolecules on the In Vivo Disposition and In situ Renal Disposition Characteristics of rhIL-11 A. TAKAGI, Y. YABE, Y. OKA, Y. TAKAKURA and M. HASHIDA	136
Separation and Determination of Diastereomeric Flurbiprofen Acyl Glucuronides in Human Urine by LC/ESI-MS with a Simple Column-Switching Technique N. MANO, T. NARUI, A. NIKAIDO and J. GOTO	142
CYP3A4 Gene Polymorphisms Influence Testosterone 6β-hydroxylation N. MURAYAMA, T. NAKAMURA, M. SAEKI, A. SOYAMA, Y. SAITO, K. SAI, S. ISHIDA, O. NAKAJIMA, M. ITODA, Y. OHNO, S. OZAWA and J. SAWADA	150

Short Communication

Determination of CYP2D6 Gene Alleles by the CYP450 Probe Array Using the Affymetrix GeneChip System: Comparison with Sequencing Results S. ISHIDA, A. SOYAMA, Y. SAITO, N. MURAYAMA, M. SAEKI, K. SAI, S. OZAWA and J. SAWADA

157

SNP Communications

Novel Mutations of the CYP2A6 Gene in a Thai Population with Lowered Capacity of Coumarin 7-Hydroxylation K. KIYOTANI, H. YAMAZAKI, M. FUJIEDA, S. DAIGO, S. SATARUG, P. UJJIN and T. KAMATAKI	SNP1 (161)
A Major Genotype in UDP-glucuronosyltransferase 2B15 K. TOIDE, S. UMEDA, H. YAMAZAKI, Y. TAKAHASHI, Y. TERAUCHI, T. FUJII and T. KAMATAKI	SNP4 (164)

Instructions to Authors

(1)